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Advice > BSAVA Guide to the Use of Veterinary Medicines > Responsible use of antimicrobial agents > Rational antimicrobial combinations
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Rational antimicrobial combinations

  • Combinations may be useful if there is a mixed infection – e.g. an aminoglycoside (Gram-negative spectrum) with clindamycin (anaerobic spectrum).
  • Synergism is described for some combinations – e.g. aminoglycosides combined with penicillins or sulphonamides combined with diaminopyrimidines.
  • Combinations may be indicated for agents where resistance develops rapidly, so that rapid bacterial killing is desirable – e.g. rifampin combined with a macrolide such as erythromycin, clarithromycin or azithromycin (in accordance with the prescribing cascade).
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